Sec-mediated secretion by Coxiella burnetii
نویسندگان
چکیده
منابع مشابه
Coxiella burnetii
Q fever has been described for the first time in 1935 as an outbreak of fever in workers of a slaughterhouse in Brisbane, Australia (Derrick, 1937). Derrick could not identify the aetiological agent therefore he defined the disease as “query fever”. Afterwards, in 1937, Burnet and Freeman (Burnet & Freeman, 1937) isolated a troublesome intracellular pathogen from mice inoculated with blood or f...
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Coxiella burnetii is an intracellular Gram-negative bacterium that causes human Q fever, a flu-like disease that can progress to chronic, life-threatening endocarditis. In humans, C. burnetii infects alveolar macrophages and promotes phagosomal fusion with autophagosomes and lysosomes, establishing a unique parasitophorous vacuole (PV) in which to replicate. The pathogen uses a Dot/Icm type IV ...
متن کاملProtein synthesis by intact Coxiella burnetii cells.
Coxiella burnetii was isolated from persistently infected fibroblast host cells by a rapid mechanical lysis technique. Macromolecular synthesis was initiated in these otherwise dormant cells by incubation at pH 4.5. The synthesis of protein proceeded for as long as 24 h. Initiation of protein synthesis in C. burnetii was dependent upon RNA synthesis. Approximately 24 species of polypeptides wer...
متن کاملCoxiella burnetii pneumonia.
This report reviews the pulmonary and extrapulmonary manifestation of infections due to Coxiella burnetii. Q fever, a zoonosis, is due to infection with C. burnetii. This spore-forming microorganism is a small gram-negative coccobacillus that is an obligate intracellular parasite. The most common animal reservoirs are goats, cattle, sheep, cats, and occasionally dogs. The organism reaches high ...
متن کاملSynthesis of serine by Coxiella burnetii.
Myers, W. F. (University of Kansas, Lawrence) and D. Paretsky. Synthesis of serine by Coxiella burnetii. J. Bacteriol. 82:761-763. 1961.-Enzyme preparations from suspensions of purified Coxiella burnetii are capable of synthesizing serine from formaldehyde and glycine-2-C(14) in the presence of tetrahydrofolic acid. Evidence for the reaction is obtained by isolating and identifying radioactive ...
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ژورنال
عنوان ژورنال: BMC Microbiology
سال: 2013
ISSN: 1471-2180
DOI: 10.1186/1471-2180-13-222